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Dopamine also enhanced LPS-mediated NO production in RAW264.7 cells, although only at higher concentrations (5 10 5 M) and to a much lesser extent than other catecholamines (Chi et al., 2003)

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However, to fully realize this possibility, I believe that future studies need to establish what pathway(s) and mechanisms link the activation of the CNS leptin-MCR4 pathway to its beneficial cardiac effects

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